AO Spine Knowledge Forum Tumor

Leading the way in spine oncology research

Goals

AOSpine KF Tumor is an international group of dedicated spine oncology surgeons and oncologists who: 

  • implement physician-driven landmark clinical studies;
  • advance patient care through multicenter analysis and peer-reviewed publications;
  • focus on both metastatic and the very rare primary spine tumors.

Ongoing research projects

  • Stabilize or Not to Stabilize
    Biomechanics-based Guidelines in Case of Indeterminate Spinal Instability Neoplastic Score (SINS)

    Principal investigator:
    Marco Palanca

    Co-Principal investigator:
    Luca Cristofolini

    Goals:
    Aims to identify the effects of metastatic lesions on the spine stability in order to create more specific and clear guidelines for the indeterminate SINS cases
  • Nanoparticles for Intramedullary Spinal Cord Tumors (IMSCT)
    Determining Efficacy and Toxicity of Magnetically Guided Nanoparticles for Intramedullary Spinal Tumors

    Principal investigator:
    Ankit I. Mehta

    Goals:
    Aims to evaluate doxorubicin-loaded magnetic nanoparticles (MNP-DOX) for IMSCTs compared to systemic and intrathecal chemotherapy in an orthotopic xenograft tumor model
  • Prognosis Evaluation of Solitary Plasmacytoma of Bone
    Exploration and Clinical Application of New Indicators for Prognosis Evaluation of Solitary Plasmacytoma of Bone

    Principal investigator:
    Hanqiang Ouyang
    Co-Principal investigators:
    Liang Jiang, Shaomin Yang

    Goals:
    Aims to use high-throughput sequencing technology to conduct genome-wide association analysis to study gene mutations related to early progression of solitary plasmacytoma of bone to multiple myeloma
  • Development of a Spine Oncology Specific Utility Score (SOSUS)

    Principal investigator:
    Nicolas Dea 

    Co-Principal investigators:
    Charles Fisher, Anne Versteeg, Arjun Sahgal, Mark Pahuta

    Goal:
    Aims to develop a valid and reliable disease-specific utility score for spine oncology

     
  • Effective Radiation Therapy Regimes for Spinal Chordoma (RT in Chordoma) 

    Principal investigator:
    Nicolas Dea

    Co-Principal investigators:
    Jeremy Reynolds, John Shin, Charles Fisher

    Goals:
    Aims to understand the current treatment strategies and identify the most effective radiation therapy regime for the treatment of spinal chordoma
    There are two aspects to this study:
    i. Expert survey based on clinical practice
    ii. Systematic literature review

    Documents:
    Publication summary

     
  • Optimal Care Pathway and Treatment Guideline for Primary Tumors of the Spine

    Principal investigator:
    Raphaële Charest-Morin

    Co-Principal investigators:
    Nicholas Dea, Arjun Sahgal, Ilya Laufer

    Goals:
    Aims to define the optimal care pathway for patients with primary spinal column tumors

  • Patient Expectations and Perceptions in Spinal Oncology (PEPSO)

    Principal investigator:
    Lenny Verkooijen

    Co-Principal investigators:
    Anne Versteeg, Charles Fisher

    Goals:
    Aims to develop an in-depth understanding of patient expectations of outcomes related to surgical treatment for spinal metastases

  • * Metastatic Tumor Research and Outcomes Network (MTRON)

    A multicenter prospective registry for the management of metastatic spine tumors

    Principal investigator:
    Charles Fisher

    Co-Principal investigators:
    Arjun Sahgal

    Goals:
    Aims to prospectively investigate the prognostic variables (clinical, diagnostic, and therapeutic) in patients diagnosed with metastatic spine tumor(s) that are associated with patient reported outcomes, morbidity, local control, and survival

    ClinicalTrials.gov Identifier: NCT02830451

  • * Primary Tumor Research and Outcomes Network (PTRON)

    A multicenter prospective registry for the management of primary tumors of the spine

    Principal investigator:
    Charles Fisher

    Co-Principal investigators:
    Ziya Gokaslan, Laurence Rhines

    Goals:
    Aims to prospectively investigate the prognostic variables (clinical, diagnostic, and therapeutic) within subgroups of patients diagnosed with primary spinal column tumors that are associated with survival, local recurrence, morbidity, and patient reported outcomes

    ClinicalTrials.gov Identifier: NCT02790983

  • */** Epidemiology, Process, and Outcomes of Spine Oncology (EPOSO)

    Principal investigator:
    Charles Fisher

    Co-Principal investigators:
    Ziya Gokaslan

    Goals:
    Aims to prospectively collect patient, diagnostic and treatment variables along with disease-specific and generic health related quality of life (HRQOL) data on consecutively treated patients with metastatic spine tumors

    Remark:
    This project received co-funding from the Orthopaedic Research & Education Foundation (OREF) through a Spine Prospective Clinical Research Grant

    Documents:
    Publication summary
    Questionnaire (SOSGOQ2.0) 
    Manuscript (SOSGOQ2.0)

    ClinicalTrials.gov Identifier: NCT01825161

*  This AO Spine-sponsored study is executed with support from AO Clinical Investigation and Documentation (AO CID).
** Award-winning project

Completed research projects

  • ** Primary Tumor Retrospective (PT Retro)

    Predictors of mortality and morbidity in the surgical management of primary tumors of the spine: a multi-center retrospective cohort study with a cross-sectional survival check

    Principal investigator:
    Charles Fisher

    Co-Principal investigators:
    Ziya Gokaslan

    Goals:
    Determined what variables (clinical, diagnostic, therapeutic, or demographic) are associated with local recurrence and survival within defined groups of primary malignant and benign bone and soft tissue spine tumors
    i. Overall analysis –  analysis of the complete collection
    ii. Histotype analysis – analysis of each tumor histotype. Each histotype (13 identified) will undergo a separate analysis by assigned project members

    Documents:
    Publication summary 

    ClinicalTrials.gov Identifier: NCT01643174

  • TERT (an extension of PT Retro)

    An analysis of the role of the TERT promoter mutations in retrospectively collected primary spinal column tumors

    Principal investigator:
    Chetan Bettegowda

    Co-Principal investigators:
    Ziya Gokaslan

    Goals:
    Determined the rates of TERT promoter mutation (mutation of the promoter of the telomerase gene [23348506,23348503]) and its prognostic significance in primary spinal column tumors

    Documents:
    Publication summary

  • FFPE Chordoma (an extension of PT Retro)

    FFPE=Formalin-Fixed Paraffin-Embedded tissue. An analysis of the role of the single nucleotide polymorphism rs2305089 in retrospectively collected chordomas

    Principal investigator:
    Chetan Bettegowda

    Co-Principal investigators:
    Stephen Yip

    Goals:
    Aimed to determine the role that the SNP rs2305089 has in the prognosis of chordoma patients by evaluating whether there is a relationship between the status of the SNP and various clinical outcomes/measures (eg, survival, local recurrence, response to radiation therapy, response to chemotherapy, link to metastasis, demographics)

    Documents:
    Publication summary

  • Systematic Reviews

    Systematic reviews about the outcomes of surgical treatment of metastases to the spine and primary tumors of the spine

    Principal investigator:
    Charles Fisher

    Co-Principal investigators:
    Michelle Clarke, Daniel Sciubba, Daryl Fourney

    Goals:

    • Performed a systematic review of the literature for prognostic factors specific to: 
      i. surgical treatment of prostate metastases to the spine 
      ii. surgical treatment of breast metastases to the spine 
      iii. surgical treatment of renal cell metastases to the spine 
      iv. surgical treatment of lung metastases to the spine 
      v. symptomatic vertebral hemangioma
    • Performed a systematic review of the literature for the management of malignant primary tumors of the spine

    Documents:

    Publication summary
  • AO Spine Oncology Focus Issue 2016

    Focus Issue II in Spine Oncology:
    Evidence-based Medicine Recommendations for Spine Oncology

    Principal investigator:
    Charles Fisher

    Goals:
    Produced a spine oncology Focus Issue which synthesizes the best available evidence and expert opinion in the management of primary spinal column tumors and metastatic spine disease

    Documents:
    Focus Issue

  • Spinal lnstability Neoplastic Score (SINS)

    Interdisciplinary validity and reliability of the SINS instability score in radiologists and radiation oncologists

    Principal investigator:
    Charles Fisher

    Goals:
    Assessed the inter- and intra-observer reliability and validity of SINS in radiologists and radiation oncologists

    Documents:
    Publication summary

** Award-winning project

KF Tumor steering committee

Charles Fisher

Chairperson
University of British Columbia
Vancouver, Canada

Stefano Boriani

Stefano Boriani

IRCCS
Istituto Ortopedico Galeazzi
Milan, Italy

Ziya Gokaslan

The Warren Alpert Medical School of Brown University
Providence, USA

Laurence Rhines

The University of Texas MD Anderson Cancer Center
Houston, USA

Chetan Bettegowda

Johns Hopkins University School of Medicine
Baltimore, USA

Arjun Sahgal

Sunnybrook Health Sciences Center
Toronto, Canada

Áron Lazáry

National Center for Spinal Disorders
Budapest, Hungary

Ilya Laufer

Ilya Laufer

Memorial Sloan-Kettering Cancer Center
New York, USA

Jeremy Reynolds

Jeremy Reynolds

Nuffield Orthopaedic Centre
Oxford, UK


KF Tumor Associate Members

Ori Barzilai, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
Mark Bilsky, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
Raphaële Charest-Morin, University of British Columbia, Vancouver, BC, Canada
Dean Chou, University of California San Francisco, San Francisco, CA, USA
Michelle Clarke, Mayo Clinic, Department of Neurologic Surgery, Rochester, MN, USA
Nicolas Dea, University of British Columbia, Vancouver, BC, Canada
Alexander Disch, Universitätsklinikum Cal Gustav Carus, Dresden, Germany
Wietse Eppinga, UMC Utrecht, Utrecht, the Netherlands
Michael Fehlings, University of Toronto, Toronto, ON, Canada
Alessandro Gasbarrini, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
Tony Goldschlager, Monash University, Melbourne, Victoria, Australia
Rory Goodwin, Duke University, Durham, NC, USA
Francis Hornicek, UCLA, Los Angeles, CA, USA
Michael Johnson, University of Manitoba, Winnipeg, Canada
Norio Kawahara, Kanazawa Medical University, Uchinada-Machi, Japan
Naresh Kumar, National University Hospital, Singapore
Alessandro Luzzati, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy
Ankit I. Mehta, University of Illinois at Chicago, Chicago, IL, USA
Addisu Mesfin, University of Rochester, Rochester, USA
Jacques Müller-Broich, Orthopedic University Hospital Friedrichsheim, Frankfurt am Main, Germany
Sten Myrehaug, Sunnybrook Health Science Center, Toronto, ON, Canada
Cordula Netzer, Universitätsspital Basel, Basel, Switzerland
John O'Toole, Rush University Medical Center, Chicago, IL, USA
Hanqiang Ouyang, Peking University Third Hospital, Beijing, China
Markian Pahuta, Henry Ford Health System, Detroit, MI, USA
Shreyaskumar Patel, The University of Texas, M.D. Anderson Cancer Center, USA
Raja Rampersaud, University of Toronto, Toronto, ON, Canada
James Schuster, Hospital of the University of Pennsylvania, USA
Joseph Schwab, Massachusetts General Hospital, Boston, MA, USA
Daniel Sciubba, Johns Hopkins University, Baltimore, MD, USA
John Shin, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Byron Stephens, Vanderbilt University, Nashville, TN, USA
William G. Jacobsen, Teixeira, Instituto do Cancer do Estado Sao Paulo, Sao Paulo, Brazil
Jorrit-Jan Verlaan, UMC Utrecht, Utrecht, the Netherlands
Michael Weber, McGill University, Montreal, QC, Canada
Feng Wei, Peking University Third Hospital, Beijing, China
Josh Yamada, Memorial Sloan-Kettering Cancer Center, New York, NY, USA


Knowledge Forum Manager

Niccole Germscheid

Niccole Germscheid

Global Research Manager

Other Knowledge Forums

KF Deformity

AOSpine KF Deformity

KF SCI

AOSpine KF Spinal Cord Injury (SCI)

KF Trauma

AOSpine KF Trauma

KF Degeneration

AOSpine KF Degenerative

“To truly advance care for spine oncology patients, we have developed an international network of spine oncology centers committed to collaborative prospective multicenter research.” 

Charles Fisher, Chairperson KF Tumor, AO Spine Research Commission member

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