AOSpine Knowledge Forum Trauma

The AOSpine KF Trauma is an international working group composed of 8 steering committee members who meet on a regular basis to discuss research, assess the best evidence for current practices, and formulate clinical studies in the domain of spinal trauma. It is charged with conducting clinical research, developing AOSpine classifications, guidelines, and outcome measures.




Steering Committee

Cumhur Öner Chairperson
University Medical Center
Utrecht, Netherlands

Alex Vaccaro
Past Chairperson
Thomas Jefferson University
Philadelphia, PA, USA

Jens Chapman
Swedish Neuroscience Institute
Seattle, WA, USA

Frank Kandziora
Unfallklinik Frankfurt
Frankfurt, Germany

Shanmuganathan Rajasekaran
Ganga Hospital
Coimbatore, India

Marcel Dvorak 
Vancouver General Hospital
Vancouver, BC, Canada

Klaus Schnake
Schön Klinik Nürnberg Fürth
Fürth, Germany

Lorin Benneker
Inselspital, University of Bern
Bern, Switzerland

Emiliano Vialle
Cajuru Hospital, Catholic University of Paraná
Curitiba, Brazil


Project overview

Status: Executing
​Project Title ​Investigator(s) ​Aim Outcomes
​Thoracolumbar Burst Fractures Thoracolumbar Burst Fractures (AOSpine A3, A4) in neurologically intact patients: an observational, multicenter cohort study comparing surgical versus non-surgical treatment
PI: Marcel Dvorak
Co-PI: Cumhur Öner

To establish and quantify the difference in the patients’ clinical outcome after surgical treatment as compared to non-surgical treatment of thoracolumbar burst fractures within the first year after treatment with the Oswestry Disability Index (ODI).

​Status: Publishing
​Project Title ​Investigator(s) ​Aim ​Outcomes
​​Outcome Measurement ​Development of an AOSpine
trauma outcome instrument
​PI: Cumhur Öner ​To develop and validate a multidisciplinary and universal outcome instrument for spinal trauma patients, which includes both the patients’ and health professionals’ perspective on health and
  • Phase 1: define core set
  • Phase 2: international consensus conference
  • Phase 3: validation
​​Publication summary
​Status: Disseminating and executing
​Project Title ​Investigator(s) ​Aim Outcomes
AOSpine Classification System Development of a spine trauma injury classification system PI: Alex Vaccaro
Co-PI: Cumhur Öner

​To develop and validate a comprehensive classification system of traumatic spine injuries 

Phase 1: thoracolumbar system—Completion
Phase 2: subaxial system—Disseminating
Phase 3: sacral system—Disseminating
Phase 4: upper cervical system—Initiation

Classification toolkits and videos​

Publication summary



​Status: Completed ​ ​ ​ ​
​Project Title ​Investigator(s) ​Aim Outcomes
​Spine Trauma Focus Issue​ ​Spine Trauma Focus Issue ​​PI: Alex Vaccaro
Co-PI: Greg Schroeder
​To synthesize the latest available knowledge regarding spine trauma and spinal cord injury controversies, AOSpine Outcome instruments, AOSpine Classification systems and presentation of cases.

Publication summary

Spine Trauma Focus Issue

Effect of Riluzole on Osteogenic Differentiation Effect of Riluzole on osteogenetic differentiation of human mesenchymal stem cells and human osteoblast
PI: Alex Vaccaro
Co-I: Cumhur Öner

To understand the effects of Riluzole on mesenchymal stem cells' ability to convert to osteoblasts, on osteogenic and differentiation and possible toxicity of the drug on these cells.

​Publication summary

​​Value of CT and MRI

​The additional value of CT and MRI in determining the fracture severity and management in spinal column injuries

​PI: Shanmuganathan Rajasekaran ​To define and determine the value of a CT scan and an MRI in addition to plain radiographs in a cohort of spinal fractures of various severities. Publication summary