AOSpine Knowledge Forum Degenerative/Biologics

The AOSpine KF Degenerative/Biologics is an international working group composed of 6 steering committee members who meet on a regular basis to discuss research, assess the best evidence for current practices, and formulate clinical studies in the domain of degenerative disease of the spine and the use of biologics. It is charged with conducting clinical research, developing AOSpine classifications, guidelines, and outcome measures.



Steering Committee

S. Tim Yoon
Emory University
Atlanta, GA, USA

Jeffrey C. Wang
Past Chairperson
USC Spine Center 
Los Angeles, CA, USA 

Hans Jörg Meisel
BG-Clinic Bergmannstrost 
Halle, Germany

Darrel Brodke
University of Utah
Salt Lake City, UT, USA

Jong-Beom Park
The Catholic University of Korea
Uijeongbu-si, South Korea 

Jim Youssef
Spine Colorado
Durango, CO, USA

Project overview

Status: Executing
​Project Title ​Investigator(s) ​Aim ​Outcomes
​Osteobiologics Classification ​AOSpine Osteobiologics Classification ​PI: S. Tim Yoon
Co-PI: Zorica Buser
​To framework to evaluate the level of evidence supporting the use of bone grafts. It will help surgeons to understand the quality of the information that is provided for each product used.
​DegenPRO ​Prospective AOSpine registry on the use of non-structural graft material (osteobiologics) in the surgical treatment of degenerative spine conditions ​​PI: S. Tim Yoon
Co-PI: Jeffrey Wang
​To better understand what kind of biologics are used in degenerative cases and to assess their effectiveness in terms of PRO, complication and fusion rates.
  • Phase 1: Feasibility phase with KF Steering Committee members
  • Phase 2: Open the registry to other members
Biologics Retrospective ​Insurance database
PI: Jeffrey Wang

To mine large databases of HIPAA-compliant orthopedic and non-orthopedic records that contain charging, reimbursement, cost, diagnosis, procedure, hospital, patient demographic and co-morbidity data and other related data that enables us to evaluate the costs and care patterns for health care services: Evaluation of trends, complications and costs associated with the use of biologics in spine surgery.

Publication summary

​Biologics Health Technology Assessment ​HTA on biologics in spine surgery ​PI: All steering committee members ​​To perform 3 systematic reviews to assess efficacy and safety of
i) ICBG compared with other types of autograft; 
ii) allograft compared with all other types of graft;
iii) DBM compared with autograft, allograft or other bone graft substitutes in cervical and thoracolumbar fusion;
iv) the use of stem cells in spine degenerative conditions.

​​Publication summary

​Status: Publishing ​ ​ ​ ​
​Project Title ​Investigator(s) ​Aim ​Outcomes
ACDF Survey Survey on the current use of structural and non-structural graft materials among spine surgeons worldwide
PI: S. Tim Yoon

To learn what kind of graft materials spine surgeons around the world use generally for their ACDF procedures.

Publication summary