AOCID (Clinical Investigation and Documentation)

For more information on the pathology specific Steering Committee members, projects, and publication summaries, download the 
Overview on global research activities of AOSpine International

AOSpine Knowledge Forums

Knowledge Forum

The AOSpine Knowledge Forums (KF) are pathology focused working groups acting on behalf of AOSpine in their domain of scientific expertise. Each forum consists of up to 10 international spine experts who meet to discuss research, assess the best evidence for current practices, and formulate clinical trials to advance their field of spine expertise.

Who is behind each Knowledge Forum? 

Every AOSpine KF has a Steering Committee with up to ten worldwide pathology specific specialists directed by one chairperson. All Steering Committee members have been selected based on their research expertise, clinical involvement, and caseload.

During the course of a research project, additional investigators who are not Steering Committee members can join and become a KF associate. AOSpine will ensure that a call for membership is open to all AOSpine members and will be announced on the webpage or through other channels. In exceptional cases, the call might be limited to specialized members (e.g. Deformity surgeons). An application form designed to identify study specific requirements must be completed to be considered for KF membership. 

For more information on Knowledge Forum projects, please click on the appropriate link below:

​KF Project​ Description​ Status​
​Tumor​ ​ ​ ​ ​ ​MTRON
(Module within Spine ReCORD)
​Metastatic Tumor Research and Outcome Network (MTRON): a multicenter prospective registry for the management of metastatic spine tumors ​Planning
(Module within Spine ReCORD)
​Primary Tumor Research and Outcome Network (PTRON): a multicenter prospective registry for the management of primary tumors of the spine ​Planning
​Spine Oncology Focus Issue ​Spine Oncology Focus Issue ​Executing - data collection​
(extension of PT Retro)
​An analysis of the role of the TERT promoter mutations in retrospectively collected primary spinal column tumors ​Executing - data collection​
​​EPOSO ​​The Epidemiology, Process and Outcomes of Spine Oncology (EPOSO): propsective cohort study for the management of metastatic spine tumors ​Executing - data collection
​Primary Tumor Retrospective ​Predictors of mortality and morbidity in the surgical management of primary tumors of the spine: a multi-center retrospective cohort study with a cross-sectional survival check ​Disseminating
​FFPE Chordoma
(extension of PT Retro)
​An analysis of the role of the SNP rs2305089 in retrospectively collected primary chordomas of the spine ​Disseminating
​Systematic Reviews​ ​Systematic reviews about the outcomes of surgical treatment of metastases to the spine and primary tumors of the spine ​Disseminating​
(Spine Instability Neoplastic Score) Spine Instability Neoplastic Score)
Interdisciplinary validity and reliability of the SINS instability score in radiologists and radiation oncologists Completion​
​Deformity ​ ​ ​ ​ASD Complication Classification ​Classification of complications in Adult Spinal Deformity (ASD) ​Planning
​FLEXIS ​FLEXIbility in Scoliosis: comparison of dynamic radiographs in determining fusion level in adolescent idiopathic scoliosis correction ​Planning
​PEEDS ​Prospective Evaluation of Elderly Deformity Surgery: a prospective observational, multicenter study ​Executing - data collection
​COSSCO ​Identification of a core outcome set for spinal deformity surgery (Core Outcome Set for SCOliosis – COSSCO) ​Executing - data collection
​Scoli-Risk 1 ​Evaluation of neurologic complications associated with surgical correction of adult spinal deformity: a prospective, observational, multi-center study ​Disseminating
​ASD Consensus ​An international consensus on the appropriate treatment for adults with spinal deformity ​Disseminating
​AIS Consensus ​An international consensus on the surgical treatment standards for adolescent idiopathic scoliosis (AIS) ​Completion​
​SCI ​ ​RISCIS ​A multi-center, randomized, placebo-controlled, double-blinded trial of efficacy and safety of Riluzole in Acute Spinal Cord Injury ​Executing - data collection
​SCI Guidelines ​A global team of clinical experts in SCI will develop evidence-based clinical guidelines for the treatment of Acute Spinal Cord Injury specific to the five selected topics ​Executing - data collection
​Database Merge ​Combination of two existing databases on patients with spinal cord injuries treated surgically (NACTN and STASCIS) to assess descriptive data on injury/surgery details, ASIA score and reported complications ​Executing - data collection

Trauma​ ​ ​


Classification Toolkit website

The development and validation of a comprehensive classification system of traumatic spine injuries: phase 1: thoracolumbar system, phase 2: subaxial system, phase 3: sacral system, and phase 4: upper cervical system

Thoracolumbar Classification Training Video

Subaxial Classification Training Video

Thoracolumbar system: Completion

Subaxial system: Executing - data collection

Sacral system: Planning

Upper cervical system: Initiation

Outcome measurement​ The development and validation of a multidisciplinary and universal outcome instrument for spinal trauma patients, which includes both the patients’ and health professionals’ perspective on health and functioning. Executing - data collection​
CT and MRI​ An analysis to define and determine the value of a CT scan and an MRI in addition to plain radiographs in a cohort of spinal fractures of various severities Disseminating
Thoracolumbar Burst Fractures AOSpine A3, A4 fractures in neurologically intact patients: An observational, multicenter cohort study comparing surgical versus non-surgical treatment Planning​

Degen / Biologics​ ​ ​ ​

DegenPRO Prospective focused registry to better understand what kind of biologics are used in degenerative cases and to assess their effectiveness in terms of PRO, complication and fusion rates Executing - data collection
​Biologics Retrospective Database mining to evaluate the trends, complications and costs associated with the use of biologics in spine surgery Executing - data analysis
ACDF Survey​ Survey based study to learn what kind of graft materials spine surgeons around the world use generally for their ACDF procedures Disseminating​
Biologics HTA Systematic reviews to assess efficacy and safety of biologics in cervical and thoracolumbar fusion Disseminating

Knowledge Forum Review Panel

The KF Review Panel functions as an overarching body to review and approve project proposals for financial feasibility, staff resources, regional versus international relevance, cooperation within sister KFs, conflicts of interest, etc. It consists of:  

Voting members

  • Chairperson of Research Commission (Shanmuganathan Rajasekaran)
  • Chairperson of International Board (Dan Riew)
  • Chairpersons of each KF (Charles Fisher, Marinus de Kleuver, Alex Vaccaro, Michael Fehlings, and Jeffrey Wang)


Study support is provided directly through AOSpine's Research department and the AO Clinical Investigation and Documentation unit.

For further information, updates and participation opportunities, please contact